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Clinical Use of Vectra Cardiovascular Risk

Vectra Cardiovascular Risk incorporates a personalized assessment of inflammation to predict a rheumatoid arthritis (RA) patient’s risk for a cardiovascular event in the next 3 years.

Vectra Cardiovascular Risk provides an actionable result at point of care that highlights the role of reducing systemic inflammation associated with RA.

Vectra Score

3 Blood
Markers

Age

Patient Clinical
Information

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Patients with RA have approximately 50% greater risk for cardiovascular disease compared to the general population.1

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30% of cardiovascular risk in patients with RA is attributed to systemic inflammation and other RA related factors.2

Traditional cardiovascular (CV) risk factors do not fully explain the increased CV risk seen in RA patients.3

Learn how Vectra Cardiovascular Risk can help you manage your patient’s cardiovascular risk associated with their rheumatoid arthritis inflammation.

The Science of Vectra Cardiovascular Risk

Vectra Cardiovascular Risk incorporates the patient’s Vectra Score, 3 blood biomarkers, age, history of diabetes, hypertension, cardiovascular disease, and tobacco use.

Vectra Cardiovascular Risk has been developed and validated utilizing over 30,000 Medicare patients with rheumatoid arthritis (RA).

Vectra Cardiovascular Risk has been externally validated in a younger independent cohort whose median age was 54.

Vectra Cardiovascular Risk is unique because it incorporates personalized multi-biomarker-based assessment of RA inflammation to predict a patient’s cardiovascular risk.

Vectra Cardiovascular Risk accurately predicts cardiovascular events in patients with Low, Moderate, or High Vectra Scores.

Vectra Cardiovascular Risk (MBDA-based CVD Risk Predictor) and Vectra Clinical Data

Derivation and Internal Validation of a Multi-Biomarker-Based Cardiovascular Disease Risk Prediction Score for Rheumatoid Arthritis Patients: Cardiovascular disease (CVD) is the leading cause of mortality for patients with rheumatoid arthritis (RA), accounting for 30–40% of deaths. Patients with RA have approximately 50% greater risk for CVD compared to the general population. Accurate CVD risk prediction could improve care for RA patients. The MBDA-based CVD risk prediction score (Vectra Cardiovascular Risk) provides rheumatologists with a tool for assessing CVD risk to inform the management of traditional CVD risk factors and RA inflammation.1

External Validation of Multi-Biomarker-Based Cardiovascular Disease Risk Prediction Score for Rheumatoid Arthritis Patients: Vectra Cardiovascular Risk was validated in a cohort younger than, and independent of, the Medicare cohort originally used for test development.

Performance of the MBDA-based CVD Risk Score in RA Patient Groups of Clinical Interest: The Vectra Cardiovascular Risk score predicts risk for myocardial infarction (MI), stroke, or fatal CVD in the next three years for rheumatoid arthritis patients and has been internally validated. Goodness of fit analyses indicated good accuracy overall, and in subgroups based on level of Vectra Score, sex, and statin use.

Biomarker-Related Risk for Myocardial Infarction and Serious Infections in Patients with Rheumatoid Arthritis: High Vectra Scores are associated with an increased risk of hospitalized infection, myocardial infarction (MI) and coronary heart disease (CHD).

Vectra Cardiovascular Risk Result

Click on the call-outs for descriptions of the highlighted areas.

Vectra Cardiovascular Risk Result gives a patient's 3-year percentage risk of a heart attack, stroke or CV related death.
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Vectra Score factors in age, sex and adiposity of the patient to provide a personalized measurement of inflammation.
X
Vectra CV Score is calculated using the Vectra Score, three biomarkers, age and clinical information to generate a score ranging from 2-6.
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The percentage risk identifies the category of cardiovascular risk for this patient. There are four categories: low, borderline, intermediate and high.
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The patient's clinical information is captured on the Test Requisition Form and provides an overview of the patient's personal history.
X
Risk Call-out Score Call-out Result Call-out Information Call-out

Vectra Cardiovascular Risk Result

Click on the call-outs for descriptions of the highlighted areas.

Vectra Cardiovascular Risk Result gives a patient's 3-year percentage risk of a heart attack, stroke or CV related death.
X
Vectra Score factors in age, sex and adiposity of the patient to provide a personalized measurement of inflammation.
X
Vectra CV Score is calculated using the Vectra Score, three biomarkers, age and clinical information to generate a score ranging from 2-6.
X
The percentage risk identifies the category of cardiovascular risk for this patient. There are four categories: low, borderline, intermediate and high.
X
The patient's clinical information is captured on the Test Requisition Form and provides an overview of the patient's personal history.
X
Risk Call-out Score Call-out Result Call-out Information Call-out

Vectra Cardiovascular Risk Result

Click on the call-outs for descriptions of the highlighted areas.

Vectra Cardiovascular Risk Result gives a patient's 3-year percentage risk of a heart attack, stroke or CV related death.
X
Vectra Score factors in age, sex and adiposity of the patient to provide a personalized measurement of inflammation.
X
Vectra CV Score is calculated using the Vectra Score, three biomarkers, age and clinical information to generate a score ranging from 2-6.
X
The percentage risk identifies the category of cardiovascular risk for this patient. There are four categories: low, borderline, intermediate and high.
X
The patient's clinical information is captured on the Test Requisition Form and provides an overview of the patient's personal history.
X
Risk Call-out Score Call-out Result Call-out Information Call-out

How to Order Vectra Cardiovascular Risk

Vectra Test Requisition Form (TRF)
The Vectra TRF has been updated to include the required information for Vectra Cardiovascular Risk. To order your patient’s Vectra Cardiovascular Risk, you must fill out section 6 on the Vectra TRF. The TRF is accessible through the clinician portal, VectraView, Vectra Customer Service at 1-877-743-8639, or the Vectra online order form.

VectraView
VectraView is an online analytical tool that enables you to draw insights from Vectra results at the individual patient or practice level and calculate your qualifying patient’s cardiovascular risk. Already order Vectra? You can calculate your patient’s Vectra Cardiovascular Risk within 90 days of a Vectra result using VectraView.

Frequently Asked Questions

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Vectra Cardiovascular Risk Clinical Data
Vectra Clinical Data